CaproMorelin Tartrate
Capromorelin Tartrate
CAS: 193273-69-7
Molecular Formula: C32H41N5O10
CaproMorelin Tartrate - Names and Identifiers
| Name | Capromorelin Tartrate |
| Synonyms | CS-2136 CP 424391-18 CP-424391 tartrate CP-424391 TARTRATE CaproMorelin Tartrate Capromorelin Tartrate Capromorelin tartrate (CP-424,391) |
| CAS | 193273-69-7 |
CaproMorelin Tartrate - Physico-chemical Properties
| Molecular Formula | C32H41N5O10 |
| Molar Mass | 655.69544 |
| Melting Point | >150oC (dec.) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Light Yellow |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Hygroscopic |
| Use | Capromorelin Tartrate is an orally available, potent growth hormone secretagogue receptor (GHSR) agonist with a Ki value of 7 nM for hGHS-R1a. |
| In vitro study | Capromorelin stimulates GH release in rat pituitary cell cultures with EC 50 of 3 nM. |
| In vivo study | Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%]. Capromorelin stimulates GH release in anesthesized rat model, with ED 50 of 0.05 mg/kg iv. |
CaproMorelin Tartrate - Reference Information
| biological activity | Capromorelin Tartrate is an orally, effective growth hormone secretagogue receptor (GHSR) agonist with a Ki value of 7 nM for hGHS-R1a. |
| target | Ki: 7 nM (hGHS-R1a) |
| in vitro study | Capromorelin stimulates GH release in rat pituitary cell cultures with EC 50 of 3 nM. |
| in vivo study | Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52kg, more than that of placebo group. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)= 65%, F(dog)= 44%]. Capromorelin stimulates GH release in anesthesized rat model, with ED 50 of 0.05 mg/kg iv. |
Last Update：2024-04-09 20:49:11
